The 'Call it Out' campaign wants people to be more than a bystander when it comes to gender-based violence.
The CFL joins the other participants which include the Ending Violence Association Canada, Status of Women Canada and the United Steelworkers.
The Ending Violence Association has been working with CFL players, coaches and staff as part of a league-wide initiative.
It began in 2015 to respond proactively to any allegation of gender-based violence.
Sunday's Grey Cup game will feature broadcast-visible LED sideline signage, an in-stadium video and an accompanying social media campaign with the message that everyone has a role to play.
CFL commissioner Randy Ambrosie says nearly 70 per cent of Canadians report that they know a woman who has experienced sexual or physical violence.