The OPP say man was killed in a head-on crash south of Hamilton on Friday morning.
Police say they were called to a two-vehicle collision in Haldimand County just before 7 a.m.
They say investigators determined that a southbound sedan and a northbound commercial vehicle collided.
Police say the driver of the sedan was pronounced dead at the scene.
The man driving the commercial motor vehicle was taken to hospital with non-life threatening injuries.
Police say the crash is still being investigated.