FedEx is severing ties with Amazon as the online retailer builds out its own delivery fleet and becomes more of a threat.
The announcement Wednesday comes two months after FedEx already terminated its air delivery contract with Amazon.
FedEx said dumping Amazon is part of its plan to go after more e-commerce deliveries from other companies.
Traditional retailers like Walmart and Target want to sell more of their goods online, which in turn allows FedEx to distance itself from Amazon.com without suffering the same competitive damage it might once have.
Amazon has been building up its own fleet of air and ground transportation to have more control over how its packages are delivered.