Biden announced his presidential campaign in a video posted to his twitter account.
A spokeswoman for Barack Obama said that having Biden as his running mate in 2008 was ``one of the best decisions he ever made''.
This will likely be the 76-year-old`s final opportunity to sit in the Oval Office.
President Donald Trump tweeted ``Welcome to the race Sleepy Joe,'' shortly after the former Vice-President made his announcement.