In a news release, the Town of Caledon confirmed that Caledon Fire and Emergency Services were called to a house fire on Maple Grove Road shortly after 6 a.m.
When crews arrived, they found that an explosion had occurred at the residence and one person was pronounced dead at the scene.
The town also said that several other houses in the area have sustained damage as a result of the blast.
Fire crews have evacuated the immediate area and are inspecting for structural damage.
The release also says OPP and Town of Caledon supports are also in the scene.
Police are expected to provide more details about the incident later this morning.