Over 2000 marijuana plants have been seized by the OPP alongside regional police.
Officers executed a search warrant on Saturday at residence in Lincoln.
Facing charges related to the Federal Cannabis Act are 24-year-old Hui Bin Chen of St. Catharines, and 24-year-old Xin Chen of Markham.
Both accused were released and are scheduled to appear before in court at a later date.
The bust is part of an ongoing effort by the OPP to eliminate the illegal cannabis supply.