Hamilton police are investigating a serious multi-vehicle collision on the Redhill Valley Parkway.
It happened near Queenston Road in the southbound lanes just after 5:30 p.m. Saturday.
Four vehicles were involved.
Hamilton paramedics say a man in his 40s was taken to a trauma centre with serious injuries.
Another person was taken to hospital with minor injuries. Four other people were assessed at the scene.
No word on the cause of the crash as police are still investigarting.